From transcriptional complexity to cellular phenotypes: Lessons from yeast | Zendy

Pelechano Vicent | Zendy

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From transcriptional complexity to cellular phenotypes: Lessons from yeast

Author(s) -

Pelechano Vicent

Publication year - 2017

Publication title -

yeast

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 102

eISSN - 1097-0061

pISSN - 0749-503X

DOI - 10.1002/yea.3277

Subject(s) - biology , transcriptome , phenotype , computational biology , gene , transcription (linguistics) , context (archaeology) , transcription factor , genetics , regulation of gene expression , gene expression , paleontology , linguistics , philosophy

Pervasive transcription has been reported in many eukaryotic organisms, revealing a highly interleaved transcriptome organization that involves thousands of coding and non‐coding RNAs. However, to date, the biological impact of transcriptome complexity is still poorly understood. Here I will review how subtle variations of the transcriptome can lead to divergent cellular phenotypes by fine‐tuning both its coding potential and regulation. I will discuss strategies that can be used to link molecular variations with divergent biological outcomes. Finally, I will explore the implication of transcriptional complexity for our understanding of gene expression in the context of cell‐to‐cell phenotypic variability. Copyright © 2017 John Wiley & Sons, Ltd.

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