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Naumovozyma castellii : an alternative model for budding yeast molecular biology
Author(s) -
Karademir Andersson Ahu,
Cohn Marita
Publication year - 2017
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.3218
Subject(s) - biology , budding yeast , saccharomyces , genome , yeast , genetics , model organism , saccharomyces cerevisiae , whole genome sequencing , lineage (genetic) , evolutionary biology , molecular evolution , computational biology , gene
Naumovozyma castellii ( Saccharomyces castellii ) is a member of the budding yeast family Saccharomycetaceae. It has been extensively used as a model organism for telomere biology research and has gained increasing interest as a budding yeast model for functional analyses owing to its amenability to genetic modifications. Owing to the suitable phylogenetic distance to S . cerevisiae , the whole genome sequence of N . castellii has provided unique data for comparative genomic studies, and it played a key role in the establishment of the timing of the whole genome duplication and the evolutionary events that took place in the subsequent genomic evolution of the Saccharomyces lineage. Here we summarize the historical background of its establishment as a laboratory yeast species, and the development of genetic and molecular tools and strains. We review the research performed on N . castellii , focusing on areas where it has significantly contributed to the discovery of new features of molecular biology and to the advancement of our understanding of molecular evolution. Copyright © 2016 John Wiley & Sons, Ltd.