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Natural gene expression variation studies in yeast
Author(s) -
Thompson Dawn A.,
Cubillos Francisco A.
Publication year - 2017
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.3210
Subject(s) - biology , phenotype , genetics , genome , allele , gene , genomics , genotype , computational biology , genetic variation , evolutionary biology
The rise of sequence information across different yeast species and strains is driving an increasing number of studies in the emerging field of genomics to associate polymorphic variants, mRNA abundance and phenotypic differences between individuals. Here, we gathered evidence from recent studies covering several layers that define the genotype–phenotype gap, such as mRNA abundance, allele‐specific expression and translation efficiency to demonstrate how genetic variants co‐evolve and define an individual's genome. Moreover, we exposed several antecedents where inter‐ and intra‐specific studies led to opposite conclusions, probably owing to genetic divergence. Future studies in this area will benefit from the access to a massive array of well‐annotated genomes and new sequencing technologies, which will allow the fine breakdown of the complex layers that delineate the genotype–phenotype map. Copyright © 2016 John Wiley & Sons, Ltd.

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