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Processing of pre‐ribosomal RNA in Saccharomyces cerevisiae
Author(s) -
Venema Jaap,
Tollervey David
Publication year - 1995
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.320111607
Subject(s) - saccharomyces cerevisiae , biology , ribosomal rna , yeast , rna , rna processing , 5.8s ribosomal rna , 18s ribosomal rna , genetics , computational biology , microbiology and biotechnology , ribosome , gene
Post‐transcriptional processing of precursor‐ribosomal RNA comprises a complex pathway of endonucleolytic cleavages, exonucleolytic digestion and covalent modifications. The general order of the various processing steps is well conserved in eukaryotic cells, but the underlying mechanisms are largely unknown. Recent analysis of pre‐rRNA processing, mainly in the yeast Saccharomyces cerevisiae , has significantly improved our understanding of this important cellular activity. Here we will review the data that have led to our current picture of yeast pre‐rRNA processing.