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Molecular characterization of a gene that confers 2‐deoxyglucose resistance in yeast
Author(s) -
Sanz Pascual,
RandezGil Francisca,
Prieto José Antonio
Publication year - 1994
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.320100907
Subject(s) - biology , yeast , deoxyglucose , gene , genetics , computational biology , biochemistry
We have isolated a gene whose expression enables yeast cells to overcome the inhibition of growth produced by the presence of 2‐deoxyglucose. The gene contains an open reading frame of 738 bp that may code for a protein of 27 100 Da. Cells carrying this gene contain high levels of a specific 2‐deoxyglucose‐6‐phosphate phosphatase. The expression of this phosphatase is increased by the presence of 2‐deoxyglucose and is constant along the growth curve. The sequence reported here has the GenBank accession number U03107.