Premium
A comparative analysis of distinctive features of yeast protein sequences
Author(s) -
Sapolsky Ronald J.,
Brendel Volker,
Karlin Samuel
Publication year - 1993
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.320091202
Subject(s) - biology , sequence (biology) , genetics , computational biology , yeast , similarity (geometry) , sequence analysis , open reading frame , chromosome , peptide sequence , evolutionary biology , dna , gene , artificial intelligence , computer science , image (mathematics)
The recently published sequence of yeast chromosome III (YCIII) provides the longest continuous stretch of a eukaryotic DNA molecule sequenced to date (315 kb). The sequence contains 116 distinct AUG‐initiated open reading frames of at least 200 codons in length, more than 50 of which had not been described previously nor bear significant similarity to known proteins. We have analysed the YCIII known and putative‐protein sequences with respect to significant statistical features which might reflect on structural and functional characteristics. The YCIII proteins have striking similarities and differences in their sequence attribute distributions compared to the corresponding distributions for all available yeast sequences and other protein collections. Nine examples of YCIII proteins with distinctive sequence features are discussed in detail.