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Identification of a gene encoding a novel zinc finger protein in Saccharomyces cerevisiae
Author(s) -
Breitwieser Wolfgang,
Schuster Tillman,
Price Clive
Publication year - 1993
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.320090512
Subject(s) - zinc finger , biology , saccharomyces cerevisiae , gene , genetics , yeast , transcription (linguistics) , transcription factor , tandem repeat , genome , linguistics , philosophy
In the course of a comprehensive genomic screen for cell cycle regulated genes in the yeast Saccharomyces cerevisiae (Price et al. , 1991) we identified and characterized a transcriptional unit encoding a putative zinc finger protein named FZF1 (EMBL accession number: X67787). This gene encodes a protein containing f ive z inc f ingers of the Cys2His2 class, three of which are positioned in tandem at the N‐terminus. The fourth and fifth finger follow after an interruption of 61 and 66 amino acids, respectively. While FZF1 is constitutively expressed at a very low level, its deletion is not essential for growth. Its similarity with known transcription factors, however, suggests that the FZF1 gene product may serve as a transcription factor in yeast.