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CDC15 , an essential cell cycle gene in Saccharomyces cerevisiae , encodes a protein kinased domain
Author(s) -
Schweitzer Bert,
Philippsen Peter
Publication year - 1991
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.320070308
Subject(s) - biology , saccharomyces cerevisiae , c raf , protein kinase a , sh3 domain , peptide sequence , protein kinase domain , autophagy related protein 13 , ddb1 , gene , kinase , biochemistry , mitogen activated protein kinase kinase , receptor tyrosine kinase , dna binding protein , transcription factor , mutant
The cell division cycle gene CDC 15 is essential for the late nucler division in the yeast Saccharomyces cerevisiae . The amino acid sequence of the 974 amino acids/110 kDa CDC 15 gene product, as deduced from the nucletide sequence, includes an aminoterminal protein kinase domain which contains a primary sequence mosaic showing patterns specific for protein serine/theonine kinases besides those for protein tyrosine kinases. Many protein kinases non‐essential for growth are known. CDC 15 represents an essential protein kinase like CDC 7 and CDC 28 . A carboxyterminal deletion of 32 amino acids renders the protein inactive.