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Genome‐wide mapping of cellular traits using yeast
Author(s) -
Parts Leopold
Publication year - 2014
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.3010
Subject(s) - biology , budding yeast , yeast , genome , model organism , computational biology , genetics , saccharomyces cerevisiae , genetic variation , allele , synthetic biology , evolutionary biology , gene
Yeast has long enjoyed superiority as a genetic model because of its short generation time and ease of generating alleles for genetic analysis. However, recent developments of guided nucleases for genome editing in higher eukaryotes, and funding pressures for translational findings, force all model organism communities to reaffirm and rearticulate the advantages of their chosen creature. Here I examine the utility of budding yeast for understanding the genetic basis of cellular traits, using natural variation as well as classical genetic perturbations, and its future prospects compared to undertaking the work in human cell lines. Will yeast remain central, or will it join the likes of phage as an early model that is no longer widely used to answer the pressing questions? Copyright © 2014 John Wiley & Sons, Ltd.