Premium
Resveratrol induces antioxidant defence via transcription factor Yap1p
Author(s) -
Escoté Xavier,
Miranda Merce,
Menoyo Sandra,
RodríguezPorrata Boris,
CarmonaGutiérrez Didac,
Jungwirth Helmut,
Madeo Frank,
Cordero Ricardo R.,
Mas Albert,
Tinahones Francisco,
Clotet Josep,
Vendrell Joan
Publication year - 2012
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.2903
Subject(s) - resveratrol , biology , antioxidant , biochemistry , transcription factor , oxidative stress , microbiology and biotechnology , gene
Resveratrol is a polyphenol suggested to play a protective role against ageing and age‐related diseases. We demonstrate that administering low‐doses of resveratrol causes ROS accumulation and transcriptional changes in yeast cells and human adipocytes. These changes in gene expression depend on the oxidative transcription factor Yap1p. In particular, resveratrol induces expression of Yap1p gene targets, such as TRX2 , TRR1 or AHP1 , in a Yap1p‐dependent mode. Under resveratrol treatment, Yap1p is phosphorylated and accumulated in the nucleus. Yap1p knockout causes resveratrol sensitivity, which totally depends on the presence of the C‐terminal region of Yap1p. Thus, resveratrol may enhance cellular lifespan by hormetic ROS accumulation, which leads to strengthening the cells' antioxidant capacity. Copyright © 2012 John Wiley & Sons, Ltd.