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Fine regulation of Saccharomyces cerevisiae MAPK pathways by post‐translational modifications
Author(s) -
Molina María,
Cid Víctor J.,
Martín Humberto
Publication year - 2010
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.1791
Subject(s) - saccharomyces cerevisiae , biology , mapk/erk pathway , yeast , computational biology , phosphoproteomics , protein kinase a , signal transduction , signalling pathways , model organism , microbiology and biotechnology , posttranslational modification , kinase , genetics , biochemistry , gene , protein phosphorylation , enzyme
Saccharomyces cerevisiae has been widely used as a model eukaryotic organism to elucidate the molecular mechanisms that operate upon activation of signalling pathways. For over two decades, many clues to the regulation of mitogen‐activated protein kinase (MAPK) pathways have derived from basic research in yeast. Here we review aspects of MAPK pathway fine‐tuning, such as the functional implication of feedback loops or regulatory inputs from other pathways, mediated by post‐transcriptional modifications on their components. The impact of recent phosphoproteomic approaches in this particular field is also discussed. Copyright © 2010 John Wiley & Sons, Ltd.