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Together we are strong—cell wall integrity sensors in yeasts
Author(s) -
Rodicio Rosaura,
Heinisch Jürgen J.
Publication year - 2010
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.1785
Subject(s) - biology , saccharomyces cerevisiae , yeast , context (archaeology) , microbiology and biotechnology , cell wall , signal transduction , cell , cell membrane , biophysics , computational biology , genetics , paleontology
The integrity of the fungal cell wall is ensured by a signal transduction pathway, the so‐called CWI pathway, which has best been studied in the model yeast Saccharomyces cerevisiae . In this context, environmental stress and other perturbations at the cell surface are detected by a small set of plasma membrane‐spanning sensors, viz. Wsc1, Wsc2, Wsc3, Mid2 and Mtl1. This review covers the recent advances in sensor structure, sensor mechanics, their cellular distribution and their in vivo functions, obtained from genetic, biochemical, cell biological and biophysical investigations. Copyright © 2010 John Wiley & Sons, Ltd.