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Genome‐wide analysis of coding DNA and amino acid variation in Saccharomyces cerevisiae
Author(s) -
Tan Haidong,
Wang Jinxia,
Yang Fan,
Zhao Zongbao K.
Publication year - 2008
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.1547
Subject(s) - biology , amino acid , dna , saccharomyces cerevisiae , genome , yeast , biochemistry , coding region , codon usage bias , genetics , genetic code , amino acid residue , gene , peptide sequence
The possible causes of variation on amino acid composition in the yeast Saccharomyces cerevisiae were investigated genome‐wide. The results indicated that: (a) the base composition of coding DNA and amino acid composition was similar among all the chromosomes, which was in sharp contrast with the great varies of the composition of the individual's coding DNA and amino acid; (b) some amino acids (e.g. Cys and Trp) were not present in all the proteins; and (c) amino acid bias was associated with a base bias (in terms of A‐, G‐, C‐ and T‐rich codons). Based on the third rule and a proposed universal trend of amino acid gain and loss in protein evolution, the changing pattern of coding DNA was predicted to be T‐ and C‐accruing, whereas A and G were consistently reducing. All these results held the potential to reveal precisely how DNA ongoing change has a major effect on the composition of proteins. Copyright © 2007 John Wiley & Sons, Ltd.