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The mitochondrial genome from the thermal dimorphic fungus Paracoccidioides brasiliensis
Author(s) -
Cardoso Maria Angélica G.,
Tambor José Humberto M.,
Nobrega Francisco G.
Publication year - 2007
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.1500
Subject(s) - biology , paracoccidioides brasiliensis , mitochondrial dna , genetics , gene , genome , intergenic region , ribosomal rna , intron , microbiology and biotechnology , transfer rna , rna
We present here the sequence of the mitochondrial DNA of the pathogenic thermodimorphic fungus Paracoccidioides brasiliensis , agent of an endemic disease in most South American countries. The sequenced genome has 71 334 bp and is organized as a circular molecule with two gaps of unknown size flanking the middle exon of the nad5 gene. We located genes coding for the three subunits of the ATP synthase ( atp6, atp8 and atp9 ), the apocytochrome b ( cob ), three subunits of the cytochrome c oxidase enzyme complex ( cox1, cox2 and cox3 ), seven subunits of the reduced nicotinamide adenine dinucleotide ubiquinone oxidoreductase ( nad1, nad2, nad3, nad4, nad5, nad6 and nad4L ) and the large ( rnl ) and small ( rns ) subunits of ribosomal RNA. Two maturases and a ribosomal protein ( rms5 ) are located inside introns. Twenty‐five tRNAs were identified with acceptors for all 20 amino acids. Seven polypurine/polypyrimidine tracts (140–240 bp) have been found in this genome. All genes are in the same orientation over the genome, while their order is closest to the mitochondrial genomes from Penicillium marneffei and Aspergillus nidulans . This sequence is available under GenBank Accession No. AY955840. Copyright © 2007 John Wiley & Sons, Ltd.