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PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin
Author(s) -
Terakawa A.,
Ishii K.,
Yamazaki H.,
Matsuyama S.,
Kikuchi Y.,
Ito Y.,
Tagawa A.,
Yasunaga S.,
Kawamura T.,
Takahashi Y.,
Hatori Y.,
Hamada N.,
Fujiki K.,
Ito N.,
Wada S.,
Funaki Y.,
Sera K.
Publication year - 2011
Publication title -
x‐ray spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.447
H-Index - 45
eISSN - 1097-4539
pISSN - 0049-8246
DOI - 10.1002/xrs.1338
Subject(s) - cisplatin , fibrosarcoma , platinum , solid tumor , chemistry , radiochemistry , chemotherapy , medicine , nuclear medicine , pathology , biochemistry , cancer , catalysis
Platinum concentration in a murine solid tumor treated with proton therapy combined with the platinum‐based chemotherapeutic agent cisplatin [ cis ‐diamminedichloro‐platinum(II) (CDDP)] was investigated with conventional and submilli‐PIXE (particle‐induced X‐ray emission) analyses. An enhanced therapeutic effect on tumor growth was observed in NFSa fibrosarcoma tumors in mice when proton therapy with a single dose of 30 Gy and CDDP treatment (10 mg/kg) were combined. The conventional PIXE analysis based on an internal standard method showed that the platinum concentration was 2.6 ± 0.3 µg/g for the tumor samples excised from the mice 6 h after the CDDP administration. The submilli‐PIXE analysis of the tumor sections showed that spatial distribution of CDDP may be more or less uniform in the tumor. Copyright © 2011 John Wiley & Sons, Ltd.