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Lineage‐instructive functions of the E26 ‐transformation‐specific‐family transcription factor Spi‐C in immune cell development and disease
Author(s) -
Raczkowski Hannah L.,
DeKoter Rodney P.
Publication year - 2021
Publication title -
wires mechanisms of disease
Language(s) - English
Resource type - Journals
ISSN - 2692-9368
DOI - 10.1002/wsbm.1519
Subject(s) - transcription factor , biology , microbiology and biotechnology , cellular differentiation , b cell , epigenetics , cell fate determination , myeloid , cell , genetics , immunology , gene , antibody
Cell fate decisions during hematopoiesis are the consequence of a complex mixture of inputs from cell‐intrinsic and cell‐extrinsic factors. In rare cases, expression of a single transcription factor, or a few key factors, may be sufficient to dictate lineage differentiation in a precursor cell. The E26‐transformation‐specific‐family transcription factor Spi‐C has emerged as an example of a lineage‐instructive factor involved in the generation of mature, specialized subsets of both myeloid and lymphoid cells. Spi‐C can instruct differentiation of splenic precursors into red pulp macrophages responsible for phagocytosing senescent red blood cells. In the B cell compartment, Spi‐C acts as a key regulator of cell fate decisions at the pro‐B to pre‐B cell stage and for plasma cell differentiation. Spi‐C regulates key genes including Nfkb1 , Bach2 , Syk , and Blnk to regulate cell cycle entry and B cell differentiation. Here, we review the biology of the lineage‐instructive transcription factor Spi‐C and its contribution to mechanisms of disease in macrophages and B cells. This article is categorized under: Cancer > Molecular and Cellular Physiology Immune System Diseases > Molecular and Cellular Physiology Infectious Diseases > Genetics/Genomics/Epigenetics