Open AccessThe best models of metabolism
Author(s) -
Voit Eberhard O.
Publication year - 2017
Publication title -
wiley interdisciplinary reviews: systems biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.087
H-Index - 51
eISSN - 1939-005X
pISSN - 1939-5094
DOI - 10.1002/wsbm.1391
Subject(s) - variety (cybernetics) , structuring , computer science , process (computing) , repertoire , management science , operations research , risk analysis (engineering) , data science , engineering , artificial intelligence , business , finance , operating system , physics , acoustics
Biochemical systems are among of the oldest application areas of mathematical modeling. Spanning a time period of over one hundred years, the repertoire of options for structuring a model and for formulating reactions has been constantly growing, and yet, it is still unclear whether or to what degree some models are better than others and how the modeler is to choose among them. In fact, the variety of options has become overwhelming and difficult to maneuver for novices and experts alike. This review outlines the metabolic model design process and discusses the numerous choices for modeling frameworks and mathematical representations. It tries to be inclusive, even though it cannot be complete, and introduces the various modeling options in a manner that is as unbiased as that is feasible. However, the review does end with personal recommendations for the choices of default models. WIREs Syst Biol Med 2017, 9:e1391. doi: 10.1002/wsbm.1391 This article is categorized under: Analytical and Computational Methods > Dynamical Methods Models of Systems Properties and Processes > Mechanistic Models Biological Mechanisms > Metabolism