Open AccessRegulatory elements in molecular networks
Author(s) -
Doane Ashley S.,
Elemento Olivier
Publication year - 2017
Publication title -
wiley interdisciplinary reviews: systems biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.087
H-Index - 51
eISSN - 1939-005X
pISSN - 1939-5094
DOI - 10.1002/wsbm.1374
Subject(s) - computational biology , regulatory sequence , variety (cybernetics) , genome , biology , gene regulatory network , focus (optics) , regulation of gene expression , computer science , gene , genetics , gene expression , artificial intelligence , physics , optics
Regulatory elements determine the connectivity of molecular networks and mediate a variety of regulatory processes ranging from DNA looping to transcriptional, posttranscriptional, and posttranslational regulation. This review highlights our current understanding of the different types of regulatory elements found in molecular networks with a focus on DNA regulatory elements. We highlight technical advances and current challenges for the mapping of regulatory elements at the genome‐wide scale, and describe new computational methods to uncover these elements via reconstructing regulatory networks from large genomic datasets. WIREs Syst Biol Med 2017, 9:e1374. doi: 10.1002/wsbm.1374 This article is categorized under: Analytical and Computational Methods > Computational Methods Laboratory Methods and Technologies > Genetic/Genomic Methods Biological Mechanisms > Regulatory Biology