Neural stem and progenitor cells in health and disease | Zendy

Ladran Ian | Zendy; Tran Ngoc | Zendy; Topol Aaron | Zendy; Brennand Kristen J. | Zendy

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Neural stem and progenitor cells in health and disease

Author(s) -

Ladran Ian,

Tran Ngoc,

Topol Aaron,

Brennand Kristen J.

Publication year - 2013

Publication title -

wiley interdisciplinary reviews: systems biology and medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.087

H-Index - 51

eISSN - 1939-005X

pISSN - 1939-5094

DOI - 10.1002/wsbm.1239

Subject(s) - progenitor cell , neural stem cell , biology , stem cell , context (archaeology) , developmental biology , progenitor , neuroscience , microbiology and biotechnology , regeneration (biology) , stem cell biology , cellular differentiation , genetics , gene , embryo , paleontology , reproductive technology , embryogenesis

Neural stem/progenitor cells ( NSPCs ) have the potential to differentiate into neurons, astrocytes, and/or oligodendrocytes. Because these cells can be expanded in culture, they represent a vast source of neural cells. With the recent discovery that patient fibroblasts can be reprogrammed directly into induced NSPCs , the regulation of NSPC fate and function, in the context of cell‐based disease models and patient‐specific cell‐replacement therapies, warrants review. WIREs Syst Biol Med 2013, 5:701–715. doi: 10.1002/wsbm.1239 This article is categorized under: Developmental Biology > Lineages Biological Mechanisms > Regulatory Biology Developmental Biology > Stem Cell Biology and Regeneration

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