Open AccessNeural stem and progenitor cells in health and disease
Author(s) -
Ladran Ian,
Tran Ngoc,
Topol Aaron,
Brennand Kristen J.
Publication year - 2013
Publication title -
wiley interdisciplinary reviews: systems biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.087
H-Index - 51
eISSN - 1939-005X
pISSN - 1939-5094
DOI - 10.1002/wsbm.1239
Subject(s) - progenitor cell , neural stem cell , biology , stem cell , context (archaeology) , developmental biology , progenitor , neuroscience , microbiology and biotechnology , stem cell biology , regeneration (biology) , cellular differentiation , genetics , gene , embryo , paleontology , reproductive technology , embryogenesis
Neural stem/progenitor cells ( NSPCs ) have the potential to differentiate into neurons, astrocytes, and/or oligodendrocytes. Because these cells can be expanded in culture, they represent a vast source of neural cells. With the recent discovery that patient fibroblasts can be reprogrammed directly into induced NSPCs , the regulation of NSPC fate and function, in the context of cell‐based disease models and patient‐specific cell‐replacement therapies, warrants review. WIREs Syst Biol Med 2013, 5:701–715. doi: 10.1002/wsbm.1239 This article is categorized under: Developmental Biology > Lineages Biological Mechanisms > Regulatory Biology Developmental Biology > Stem Cell Biology and Regeneration