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Functions and mechanisms of spliceosomal small nuclear RNA pseudouridylation
Author(s) -
Wu Guowei,
Yu Andrew T.,
Kantartzis Athena,
Yu YiTao
Publication year - 2011
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.77
Subject(s) - small nuclear rna , rna , ribonucleoprotein , rna splicing , spliceosome , pseudouridine , small nucleolar rna , snrnp , non coding rna , rna editing , guide rna , messenger rna , biology , computational biology , genetics , transfer rna , gene , genome , cas9
Pseudouridines are the most abundant and highly conserved modified nucleotides identified in spliceosomal small nuclear RNAs (snRNAs). Most pseudouridines are also clustered in functionally important regions of spliceosomal snRNAs. Experiments carried out in several independent experimental systems show that the pseudouridines in spliceosomal snRNAs are functionally important for pre‐messenger RNA (mRNA) splicing. Experimental data also indicate that spliceosomal snRNA pseudouridylation can be catalyzed by both RNA‐dependent (box H/ACA Ribonucleoproteins) and RNA‐independent (protein‐only enzymes) mechanisms. WIREs RNA 2011 2 571–581 DOI: 10.1002/wrna.77 This article is categorized under: RNA Processing > RNA Editing and Modification