Premium
Eukaryotic 5S rRNA biogenesis
Author(s) -
Ciganda Martin,
Williams Noreen
Publication year - 2011
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.74
Subject(s) - rna , 5.8s ribosomal rna , ribosomal rna , ribosome , ribosome biogenesis , translation (biology) , nucleolus , eukaryotic ribosome , internal ribosome entry site , computational biology , microbiology and biotechnology , biology , non coding rna , genetics , messenger rna , gene , cytoplasm
The ribosome is a large complex containing both protein and RNA which must be assembled in a precise manner to allow proper functioning in the critical role of protein synthesis. 5S rRNA is the smallest of the RNA components of the ribosome, and although it has been studied for decades, we still do not have a clear understanding of its function within the complex ribosome machine. It is the only RNA species that binds ribosomal proteins prior to its assembly into the ribosome. Its transport into the nucleolus requires this interaction. Here we present an overview of some of the key findings concerning the structure and function of 5S rRNA and how its association with specific proteins impacts its localization and function. WIREs RNA 2011 2 523–533 DOI: 10.1002/wrna.74 This article is categorized under: Translation > Translation Mechanisms RNA Processing > RNA Editing and Modification RNA Processing > tRNA Processing RNA in Disease and Development > RNA in Disease