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Long noncoding RNAs in mammalian cells: what, where, and why?
Author(s) -
Chen LingLing,
Carmichael Gordon G.
Publication year - 2010
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.5
Subject(s) - polyadenylation , rna , long non coding rna , biology , non coding rna , riboswitch , computational biology , small nucleolar rna , encode , rna interference , gene expression , gene , open reading frame , genetics , microbiology and biotechnology , peptide sequence
Not all long, polyadenylated cellular RNAs encode polypeptides. In recent years, it has become apparent that a number of organisms express abundant amounts of transcripts that lack open reading frames or that are retained in the nucleus. Rather than accumulating silently in the cell, we now know that many of these long noncoding RNAs (lncRNAs) play important roles in nuclear architecture or in the regulation of gene expression. Here, we discuss some recent progress in our understanding of the functions of a number of important lncRNAs in mammalian cells. Copyright © 2010 John Wiley & Sons, Ltd. This article is categorized under: RNA Processing > RNA Editing and Modification Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA in Disease and Development > RNA in Development