Premium
Dynamics and kinetics of nucleo‐cytoplasmic mRNA export
Author(s) -
Mor Amir,
ShavTal Yaron
Publication year - 2010
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.41
Subject(s) - nuclear export signal , microbiology and biotechnology , messenger rna , nuclear pore , cytoplasm , transcription (linguistics) , ribosome , nuclear transport , translation (biology) , cell nucleus , chemistry , gene expression , rna , biology , gene , biochemistry , linguistics , philosophy
Activation of the gene expression pathway in eukaryotic cells results in the nuclear transcription of mRNA molecules, many of which are destined for translation into protein by cytoplasmic ribosomes. mRNA transcripts are exported from the nucleus to the cytoplasm via passage through nuclear pore complexes (NPCs), ∼125 MDa supramolecular complexes set in the double‐membraned nuclear envelope. Understanding the kinetics of mRNA translocation, from the point of transcription through export, localization, translation, and degradation, is of fundamental interest since gene expression is regulated at all the different levels of this pathway. In this review, we delineate the steps taken by an mRNA molecule in transit to the nuclear envelope and during mRNA export, with specific focus on the dynamic aspects of nucleo‐cytoplasmic mRNA transport as revealed by electron microscopy and live‐cell imaging. Copyright © 2010 John Wiley & Sons, Ltd. This article is categorized under: RNA Export and Localization > Nuclear Export/Import