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No‐go decay: a quality control mechanism for RNA in translation
Author(s) -
Harigaya Yuriko,
Parker Roy
Publication year - 2010
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.17
Subject(s) - rna , translation (biology) , ribosome , messenger rna , microbiology and biotechnology , protein biosynthesis , cleavage (geology) , biology , nonsense mediated decay , computational biology , chemistry , genetics , gene , fracture (geology) , rna splicing , paleontology
Abstract Eukaryotic cells have evolved multiple quality control mechanisms that recognize and eliminate defective mRNA during the process of translation. One mechanism, referred to as No‐go decay (NGD), targets mRNAs with elongation stalls for degradation initiated by endonucleolytic cleavage in the vicinity of the stalled ribosome. NGD is promoted by the evolutionarily conserved Dom34 and Hbs1 proteins, which are related to the translation termination factors eRF1 and eRF3, respectively. NGD is likely to occur by Dom34/Hbs1 interacting with the A site in the ribosome leading to release of the peptide or peptidyl‐tRNA. The process of NGD and/or the function of Dom34/Hbs1 appear to be important in several different biological contexts. Copyright © 2010 John Wiley & Sons, Ltd. This article is categorized under: RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms RNA Turnover and Surveillance > Regulation of RNA Stability