Premium
The interface between coronaviruses and host cell RNA biology: Novel potential insights for future therapeutic intervention
Author(s) -
Mara David G.,
Anderson John R.,
Mara Abril G.,
Wilusz Jeffrey
Publication year - 2020
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1614
Subject(s) - rna , biology , polyadenylation , computational biology , translation (biology) , rna binding protein , coronaviridae , effector , coronavirus , riboswitch , non coding rna , covid-19 , microbiology and biotechnology , messenger rna , disease , genetics , gene , medicine , infectious disease (medical specialty) , pathology
Coronaviruses, including SARS‐Cov‐2, are RNA‐based pathogens that interface with a large variety of RNA‐related cellular processes during infection. These processes include capping, polyadenylation, localization, RNA stability, translation, and regulation by RNA binding proteins or noncoding RNA effectors. The goal of this article is to provide an in‐depth perspective on the current state of knowledge of how various coronaviruses interact with, usurp, and/or avoid aspects of these cellular RNA biology machineries. A thorough understanding of how coronaviruses interact with RNA‐related posttranscriptional processes in the cell should allow for new insights into aspects of viral pathogenesis as well as identify new potential avenues for the development of anti‐coronaviral therapeutics. This article is categorized under: RNA in Disease and Development > RNA in Disease