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Transcription and splicing: A two‐way street
Author(s) -
Tellier Michael,
Maudlin Isabella,
Murphy Shona
Publication year - 2020
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1593
Subject(s) - rna splicing , rna polymerase ii , exonic splicing enhancer , transcription (linguistics) , rna polymerase ii holoenzyme , post transcriptional modification , general transcription factor , biology , exon , genetics , alternative splicing , microbiology and biotechnology , rna , rna polymerase , gene expression , gene , promoter , linguistics , philosophy
RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the transcription cycle of protein‐coding genes. This coupling affords opportunities for quality control and regulation of gene expression and the effects can go in both directions. For example, polymerase speed can affect splice site selection and splicing can increase transcription and affect the chromatin landscape. Here we review the many ways that transcription and splicing influence one another, including how splicing "talks back" to transcription. We will also place the connections between transcription and splicing in the context of other RNA processing events that define the exons that will make up the final mRNA. This article is categorized under: RNA Processing > Splicing Mechanisms RNA Processing > Splicing Regulation/Alternative Splicing