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Ancient and modern: hints of a core post‐transcriptional network driving chemotherapy resistance in ovarian cancer
Author(s) -
Blagden Sarah,
Abdel Mouti Mai,
Chettle James
Publication year - 2017
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1432
Subject(s) - microrna , biology , rna , ovarian cancer , translation (biology) , gene , context (archaeology) , rna binding protein , computational biology , non coding rna , long non coding rna , transcriptome , gene expression , cancer , bioinformatics , messenger rna , cancer research , genetics , paleontology
RNA ‐binding proteins ( RBPs ) and noncoding (nc) RNAs (such as microRNAs , long ncRNAs , and others) cooperate within a post‐transcriptional network to regulate the expression of genes required for many aspects of cancer behavior including its sensitivity to chemotherapy. Here, using an RBP ‐centric approach, we explore the current knowledge surrounding contributers to post‐transcriptional gene regulation ( PTGR ) in ovarian cancer and identify commonalities that hint at the existence of an evolutionarily conserved core PTGR network. This network regulates survival and chemotherapy resistance in the contemporary context of the cancer cell. There is emerging evidence that cancers become dependent on PTGR factors for their survival. Further understanding of this network may identify innovative therapeutic targets as well as yield crucial insights into the hard‐wiring of many malignancies, including ovarian cancer. WIREs RNA 2018, 9:e1432. doi: 10.1002/wrna.1432 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications Translation > Translation Mechanisms RNA in Disease and Development > RNA in Disease