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Cell cycle RNA regulons coordinating early lymphocyte development
Author(s) -
Galloway Alison,
Turner Martin
Publication year - 2017
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1419
Subject(s) - regulon , biology , microbiology and biotechnology , rna , cell cycle , rna binding protein , transcription (linguistics) , proteome , gene expression , transcription factor , cell , gene , computational biology , genetics , linguistics , philosophy
Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post‐transcriptional and post‐translational regulators to determine the proteome. Furthermore, the post‐transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway. Here, we review recent evidence demonstrating the importance of RNA binding proteins that control the cell cycle in lymphocyte development and discuss the implications for tumorigenesis. WIREs RNA 2017, 8:e1419. doi: 10.1002/wrna.1419 This article is categorized under: RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development