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mRNA localization as a rheostat to regulate subcellular gene expression
Author(s) -
Kejiou Nevraj S.,
Palazzo Alexander F.
Publication year - 2017
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1416
Subject(s) - subcellular localization , messenger rna , translation (biology) , rna , microbiology and biotechnology , gene silencing , p bodies , biology , protein subcellular localization prediction , rna silencing , protein biosynthesis , gene expression , rna binding protein , gene , rna interference , genetics , cytoplasm
It is currently believed that certain messenger RNAs ( mRNAs ) are localized to distinct subcellular regions to efficiently target their encoded proteins. However, this simplistic model does not explain why in certain scenarios mRNA localization is dispensable for proper protein distribution. In other cases, mRNA localization is accompanied by translational silencing and degradation by the localization machinery. Here we propose that in certain scenarios mRNAs are localized so that they can either be stabilized and translated, or silenced and degraded, in response to the needs of the subcellular locale. In these cases, the localized mRNA , and its cadre of associated factors, act as a rheostat that regulates protein production and/or mRNA stability in response to the needs of its immediate subcellular environment. WIREs RNA 2017, 8:e1416. doi: 10.1002/wrna.1416 This article is categorized under: Translation > Translation Regulation RNA Export and Localization > RNA Localization RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms