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Posttranscriptional regulation of intestinal epithelial integrity by noncoding RNAs
Author(s) -
Wang JunYao,
Xiao Lan,
Wang JianYing
Publication year - 2016
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1399
Subject(s) - microbiology and biotechnology , biology , microrna , translation (biology) , non coding rna , rna , long non coding rna , function (biology) , regulation of gene expression , regeneration (biology) , rna binding protein , intestinal epithelium , gene expression , intestinal mucosa , gene , epithelium , messenger rna , genetics , medicine
Maintenance of the gut epithelial integrity under stressful environments requires epithelial cells to rapidly elicit changes in gene expression patterns to regulate their survival, adapt to stress, and keep epithelial homeostasis. Disruption of the intestinal epithelial integrity occurs commonly in patients with various critical illnesses, leading to the translocation of luminal toxic substances and bacteria to the blood stream. Recently, noncoding RNAs ( ncRNAs ) have emerged as a novel class of master regulators of gene expression and are fundamentally involved in many aspects of gut mucosal regeneration, protection, and epithelial barrier function. Here, we highlight the roles of several intestinal epithelial tissue‐specific microRNAs , including miR ‐222, miR ‐29b, miR ‐503, and miR ‐195, and long ncRNAs such as H19 and SPRY4‐IT1 in the regulation of cell proliferation, apoptosis, migration, and cell‐to‐cell interactions and also further analyze the mechanisms through which ncRNAs and their interactions with RNA ‐binding proteins modulate the stability and translation of target mRNAs . WIREs RNA 2017, 8:e1399. doi: 10.1002/wrna.1399 This article is categorized under: Translation > Translation Regulation RNA Turnover and Surveillance > Regulation of RNA Stability RNA in Disease and Development > RNA in Disease