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mRNA methylation by NSUN2 in cell proliferation
Author(s) -
Wang Wengong
Publication year - 2016
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1380
Subject(s) - methylation , messenger rna , methyltransferase , rna , rna methylation , microbiology and biotechnology , cell growth , biology , dna methylation , translation (biology) , cell , epigenetics , genetics , gene expression , gene
Methylation is a prevalent post‐transcriptional modification that occurs in almost all RNA species. NSUN2 , a nucleolar RNA methyltransferase, has been shown to methylate mRNAs encoding factors that control cell division and growth arrest, thereby affecting their stability and/or translation. Here, the author summarizes the recent progress in understanding NSUN2 ‐mediated mRNA methylation and its implications in cell proliferation and senescence. WIREs RNA 2016, 7:838–842. doi: 10.1002/wrna.1380 This article is categorized under: RNA Structure and Dynamics > RNA Structure, Dynamics, and Chemistry Translation > Translation Regulation RNA Turnover and Surveillance > Regulation of RNA Stability