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Dual roles of DNA repair enzymes in RNA biology/post‐transcriptional control
Author(s) -
Vohhodina Jekaterina,
Harkin D. Paul,
Savage Kienan I.
Publication year - 2016
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1353
Subject(s) - dna , rna , microbiology and biotechnology , enzyme , biology , chemistry , computational biology , genetics , biochemistry , gene
Despite consistent research into the molecular principles of the DNA damage repair pathway for almost two decades, it has only recently been found that RNA metabolism is very tightly related to this pathway, and the two ancient biochemical mechanisms act in alliance to maintain cellular genomic integrity. The close links between these pathways are well exemplified by examining the base excision repair pathway, which is now well known for dual roles of many of its members in DNA repair and RNA surveillance, including APE1 , SMUG1 , and PARP1 . With additional links between these pathways steadily emerging, this review aims to provide a summary of the emerging roles for DNA repair proteins in the post‐transcriptional regulation of RNAs . WIREs RNA 2016, 7:604–619. doi: 10.1002/wrna.1353 This article is categorized under: RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms RNA Turnover and Surveillance > Regulation of RNA Stability RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications