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Diverse roles of the nucleic acid‐binding protein KHSRP in cell differentiation and disease
Author(s) -
Briata Paola,
Bordo Domenico,
Puppo Margherita,
Gorlero Franco,
Rossi Martina,
PerroneBizzozero Nora,
Gherzi Roberto
Publication year - 2015
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1327
Subject(s) - rna , rna splicing , nucleic acid , rna binding protein , biology , gene expression , microbiology and biotechnology , gene , cell , nucleic acid metabolism , biochemistry
The single‐stranded nucleic acid‐binding protein KHSRP ( KH ‐type splicing regulatory protein) modulates RNA life and gene expression at various levels. KHSRP controls important cellular functions as different as proliferation, differentiation, metabolism, and response to infectious agents. We summarize and discuss experimental evidence providing a potential link between changes in KHSRP expression/function and human diseases including neuromuscular disorders, obesity, type II diabetes, and cancer. WIREs RNA 2016, 7:227–240. doi: 10.1002/wrna.1327 This article is categorized under: RNA Interactions with Proteins and Other Molecules > RNA–Protein Complexes RNA Turnover and Surveillance > Regulation of RNA Stability RNA in Disease and Development > RNA in Disease