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Regulatory RNAs discovered in unexpected places
Author(s) -
Pek Jun Wei,
Okamura Katsutomo
Publication year - 2015
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1309
Subject(s) - non coding rna , rna , computational biology , biology , intron , riboswitch , gene , long non coding rna , genetics , microrna , rna interference , genomics , small nucleolar rna , genome
Recent studies have discovered both small and long noncoding RNAs ( ncRNAs ) encoded in unexpected places. These ncRNA genes were surprises at the time of their discovery, but many quickly became well‐accepted families of functional regulatory RNA species. Even after years of extensive gene annotation studies using high‐throughput sequencing technologies, new types of ncRNA genes continue to be discovered in unexpected places. We highlight ncRNAs that have atypical structures and that are encoded in what are generally considered ‘junk’ sequences, such as spacers and introns. We also discuss current bottlenecks in the approaches for identifying novel ncRNAs and the possibility that many remain to be discovered. WIREs RNA 2015, 6:671–686. doi: 10.1002/wrna.1309 This article is categorized under: RNA Evolution and Genomics > Computational Analyses of RNA RNA Turnover and Surveillance > Regulation of RNA Stability Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs