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Ilf3 and NF90 functions in RNA biology
Author(s) -
Castella Sandrine,
Bernard Rozenn,
Corno Mélanie,
Fradin Aurélie,
Larcher JeanChristophe
Publication year - 2014
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1270
Subject(s) - rna , rna binding protein , rna silencing , biology , non coding rna , microbiology and biotechnology , translation (biology) , transcription (linguistics) , computational biology , gene , rna interference , messenger rna , genetics , linguistics , philosophy
Double‐stranded RNA ‐binding proteins ( DRBPs ) are known to regulate many processes of RNA metabolism due, among others, to the presence of double‐stranded RNA ( dsRNA )‐binding motifs ( dsRBMs ). Among these DRBPs , Interleukin enhancer‐binding factor 3 (Ilf3) and Nuclear Factor 90 ( NF90 ) are two ubiquitous proteins generated by mutually exclusive and alternative splicings of the Ilf3 gene. They share common N‐terminal and central sequences but display specific C‐terminal regions. They present a large heterogeneity generated by several post‐transcriptional and post‐translational modifications involved in their subcellular localization and biological functions. While Ilf3 and NF90 were first identified as activators of gene expression, they are also implicated in cellular processes unrelated to RNA metabolism such as regulation of the cell cycle or of enzymatic activites. The implication of Ilf3 and NF90 in RNA biology will be discussed with a focus on eukaryote transcription and translation regulation, on viral replication and translation as well as on noncoding RNA field. WIREs RNA 2015, 6:243–256. doi: 10.1002/wrna.1270 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein–RNA Recognition RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications