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Cotranscriptional events in eukaryotic ribosome synthesis
Author(s) -
Turowski Tomasz W.,
Tollervey David
Publication year - 2014
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1263
Subject(s) - ribosome biogenesis , nucleoplasm , ribosomal rna , biology , 5.8s ribosomal rna , microbiology and biotechnology , ribosome , rna polymerase i , eukaryotic ribosome , genetics , rna , nucleolus , rna polymerase , gene , cytoplasm
Eukaryotic ribosomes are synthesized in a complex, multistep pathway. This begins with transcription of the rDNA genes by a specialized RNA polymerase, accompanied by the cotranscriptional binding of large numbers of ribosome synthesis factors, small nucleolar RNAs and ribosomal proteins. Cleavage of the nascent transcript releases the early pre‐40S and pre‐60S particles, which acquire export competence in the nucleoplasm prior to translocation through the nuclear pore complexes and final maturation to functional ribosomal subunits in the cytoplasm. This review will focus on the many and complex interactions occurring during pre‐rRNA synthesis, particularly in budding yeast in which the pathway is best understood. WIREs RNA 2015, 6:129–139. doi: 10.1002/wrna.1263 This article is categorized under: Translation > Ribosome Biogenesis RNA Processing > rRNA Processing