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Emerging mechanisms of mRNP remodeling regulation
Author(s) -
Chen ChyiYing A.,
Shyu AnnBin
Publication year - 2014
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1241
Subject(s) - messenger rnp , ribonucleoprotein , rna , messenger rna , biology , microbiology and biotechnology , rna binding protein , computational biology , function (biology) , genetics , gene
The assembly and remodeling of the components of messenger ribonucleoprotein particles ( mRNPs ) are important in determining the fate of a messenger RNA ( mRNA ). A combination of biochemical and cell biology research, recently complemented by genome‐wide high‐throughput approaches, has led to significant progress on understanding the formation, dynamics, and function of mRNPs . These studies also advanced the challenging process of identifying the evolving constituents of individual mRNPs at various stages during an mRNA 's lifetime. While research on mRNP remodeling in general has been gaining momentum, there has been relatively little attention paid to the regulatory aspect of mRNP remodeling. Here, we discuss the results of some new studies and potential mechanisms for regulation of mRNP remodeling. WIREs RNA 2014, 5:713–722. doi: 10.1002/wrna.1241 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications