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Battle against RNA oxidation: molecular mechanisms for reducing oxidized RNA to protect cells
Author(s) -
Li Zhongwei,
Malla Sulochan,
Shin Brian,
Li James M.
Publication year - 2013
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1214
Subject(s) - rna , rna binding protein , microbiology and biotechnology , non coding rna , chemistry , biology , biochemistry , gene
Oxidation is probably the most common type of damage that occurs in cellular RNA . Oxidized RNA may be dysfunctional and is implicated in the pathogenesis of age‐related human diseases. Cellular mechanisms controlling oxidized RNA have begun to be revealed. Currently, a number of ribonucleases and RNA ‐binding proteins have been shown to reduce oxidized RNA and to protect cells under oxidative stress. Although information about how these factors work is still very limited, we suggest several mechanisms that can be used to minimize oxidized RNA in various organisms. This article is categorized under: RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms RNA in Disease and Development > RNA in Disease