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Expression of mature messenger  RNA s ( mRNAs ) requires appropriate transcription initiation and termination, as well as pre‐ mRNA  processing by capping, splicing, cleavage, and polyadenylation. A core 3′‐end processing complex carries out the cleavage and polyadenylation reactions, but many proteins have been implicated in the selection of polyadenylation sites among the multiple alternatives that eukaryotic genes typically have. In recent years, high‐throughput approaches to map both the 3′‐end processing sites as well as the binding sites of proteins that are involved in the selection of cleavage sites and in the processing reactions have been developed. Here, we review these approaches as well as the insights into the mechanisms of polyadenylation that emerged from genome‐wide studies of polyadenylation across a range of cell types and states.  WIREs RNA  2014, 5:183–196. doi: 10.1002/wrna.1206  This article is categorized under:  RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications  RNA Processing > 3' End Processing  RNA Methods > RNA Analyses in Cells

Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors