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YB ‐1 protein: functions and regulation
Author(s) -
Lyabin Dmitry N.,
Eliseeva Irina A.,
Ovchinnikov Lev P.
Publication year - 2013
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1200
Subject(s) - rna splicing , messenger rna , rna binding protein , rna , microbiology and biotechnology , cold shock domain , dna , alternative splicing , transcription (linguistics) , translation (biology) , biology , computational biology , genetics , gene , linguistics , philosophy
The Y‐box binding protein 1 ( YB ‐1, YBX1 ) is a member of the family of DNA ‐ and RNA ‐binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into a group of intrinsically disordered proteins that do not follow the classical rule ‘one protein–one function’ but introduce a novel principle stating that a disordered structure suggests many functions. YB ‐1 participates in a wide variety of DNA / RNA ‐dependent events, including DNA reparation, pre‐ mRNA transcription and splicing, mRNA packaging, and regulation of mRNA stability and translation. At the cell level, the multiple activities of YB ‐1 are manifested as its involvement in cell proliferation and differentiation, stress response, and malignant cell transformation. WIREs RNA 2014, 5:95–110. doi: 10.1002/wrna.1200 This article is categorized under: RNA Interactions with Proteins and Other Molecules > RNA–Protein Complexes RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications Translation > Translation Regulation