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Regulation of flavivirus RNA synthesis and capping
Author(s) -
Saeedi Bejan J.,
Geiss Brian J.
Publication year - 2013
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1191
Subject(s) - rna , flavivirus , biology , non coding rna , rna editing , genome , rna dependent rna polymerase , genetics , intron , virology , computational biology , gene , virus
RNA viruses, such as flaviviruses, are able to efficiently replicate and cap their RNA genomes in vertebrate and invertebrate cells. Flaviviruses use several specialized proteins to first make an uncapped negative strand copy of the viral genome that is used as a template for the synthesis of large numbers of capped genomic RNAs . Despite using relatively simple mechanisms to replicate their RNA genomes, there are significant gaps in our understanding of how flaviviruses switch between negative and positive strand RNA synthesis and how RNA capping is regulated. Recent work has begun to provide a conceptual framework for flavivirus RNA replication and capping and shown some surprising roles for genomic RNA during replication and pathogenesis. WIREs RNA 2013, 4:723–735. doi: 10.1002/wrna.1191 This article is categorized under: RNA Processing > Capping and 5' End Modifications RNA in Disease and Development > RNA in Disease