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Signals for pre‐mRNA cleavage and polyadenylation
Author(s) -
Tian Bin,
Graber Joel H.
Publication year - 2011
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.116
Subject(s) - polyadenylation , cleavage and polyadenylation specificity factor , cleavage (geology) , cleavage factor , messenger rna , post transcriptional modification , cleavage stimulation factor , rna , rna processing , directionality , coding region , biology , microbiology and biotechnology , precursor mrna , chemistry , genetics , rna binding protein , rna splicing , gene , paleontology , fracture (geology)
Pre‐mRNA cleavage and polyadenylation is an essential step for 3′ end formation of almost all protein‐coding transcripts in eukaryotes. The reaction, involving cleavage of nascent mRNA followed by addition of a polyadenylate or poly(A) tail, is controlled by cis ‐acting elements in the pre‐mRNA surrounding the cleavage site. Experimental and bioinformatic studies in the past three decades have elucidated conserved and divergent elements across eukaryotes, from yeast to human. Here we review histories and current models of these elements in a broad range of species. WIREs RNA 2012, 3:385–396. doi: 10.1002/wrna.116 This article is categorized under: RNA Processing > 3' End Processing