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The GA‐minor submotif as a case study of RNA modularity, prediction, and design
Author(s) -
Grabow Wade W.,
Zhuang Zhuoyun,
Shea JoanEmma,
Jaeger Luc
Publication year - 2013
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1153
Subject(s) - rna , computational biology , nucleic acid structure , intron , modularity (biology) , non coding rna , ribonucleoprotein , riboswitch , structural motif , rnase p , ribozyme , biology , folding (dsp implementation) , genetics , biochemistry , gene , engineering , electrical engineering
Complex natural RNAs such as the ribosome, group I and group II introns, and RNase P exemplify the fact that three‐dimensional (3D) RNA structures are highly modular and hierarchical in nature. Tertiary RNA folding typically takes advantage of a rather limited set of recurrent structural motifs that are responsible for controlling bends or stacks between adjacent helices. Herein, the GA minor and related structural motifs are presented as a case study to highlight several structural and folding principles, to gain further insight into the structural evolution of naturally occurring RNAs, as well as to assist the rational design of artificial RNAs. WIREs RNA 2013, 4:181–203. doi: 10.1002/wrna.1153 This article is categorized under: RNA Structure and Dynamics > RNA Structure, Dynamics, and Chemistry RNA Evolution and Genomics > RNA and Ribonucleoprotein Evolution