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The human mitochondrial transcriptome and the RNA‐binding proteins that regulate its expression
Author(s) -
Rackham Oliver,
Mercer Timothy R.,
Filipovska Aleksandra
Publication year - 2012
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1128
Subject(s) - transcriptome , biology , mitochondrial dna , gene expression , rna , rna binding protein , microbiology and biotechnology , mitochondrion , gene , regulation of gene expression , genetics , mt rnr1
The human mitochondrial transcriptome, although produced from a small and compact genome, has revealed surprising complexity in its composition and regulation. Wide variation between individual tRNAs, mRNAs, and rRNAs indicate the importance of post‐transcriptional processing, maturation, and degradation mechanisms in the regulation of mitochondrial gene expression. RNA‐binding proteins play essential roles in controlling the mitochondrial transcriptome from its synthesis to its destruction and have evolved unique features to complement the unusual features of mitochondrial RNAs. Recent studies have shown how changes in mitochondrial RNAs and their binding proteins can have significant effects on human health. This opens new avenues for investigation of mitochondrial RNA‐binding proteins and the mechanisms by which they regulate mitochondrial gene expression. WIREs RNA 2012 doi: 10.1002/wrna.1128 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications RNA in Disease and Development > RNA in Disease RNA Methods > RNA Analyses In Vitro and In Silico RNA Methods > RNA Analyses in Cells