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Aging—RNA in development and disease
Author(s) -
Cookson Mark R.
Publication year - 2011
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.109
Subject(s) - rna , disease , rna binding protein , biology , non coding rna , genetics , computational biology , medicine , gene
Given that RNA is involved in virtually all biological processes, it is perhaps not surprising that several RNA‐binding proteins are associated with aging and with different age‐related disorders. Other articles in this volume will discuss some specific examples of diseases where RNA plays a role that are also associated with aging, such as cancer and inflammation, so here I will discuss some general aspects of how RNA changes with the aging process. I will also discuss some specific examples of RNA‐binding proteins that are associated with age‐dependent neurological diseases as these provide an interesting framework to examine how lifetime mutations might lead to a late onset disease, although the answers to these questions are still not well understood. WIREs RNA 2012, 3:133–143. doi: 10.1002/wrna.109 This article is categorized under: RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development