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The importance of CELF control: molecular and biological roles of the CUG‐BP, Elav‐like family of RNA‐binding proteins
Author(s) -
Dasgupta Twishasri,
Ladd Andrea N.
Publication year - 2011
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.107
Subject(s) - rna binding protein , rna splicing , rna , biology , translation (biology) , rna editing , riboswitch , messenger rna , alternative splicing , post transcriptional regulation , microbiology and biotechnology , non coding rna , genetics , regulation of gene expression , gene
RNA processing is important for generating protein diversity and modulating levels of protein expression. The CUG‐BP, Elav‐like family (CELF) of RNA‐binding proteins regulate several steps of RNA processing in the nucleus and cytoplasm, including pre‐mRNA alternative splicing, C to U RNA editing, deadenylation, mRNA decay, and translation. In vivo , CELF proteins have been shown to play roles in gametogenesis and early embryonic development, heart and skeletal muscle function, and neurosynaptic transmission. Dysregulation of CELF‐mediated programs has been implicated in the pathogenesis of human diseases affecting the heart, skeletal muscles, and nervous system. WIREs RNA 2012, 3:104–121. doi: 10.1002/wrna.107 This article is categorized under: Translation > Translation Regulation RNA Processing > Splicing Regulation/Alternative Splicing RNA Turnover and Surveillance > Regulation of RNA Stability Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs