Quantitative magnetic resonance fluorine imaging: today and tomorrow | Zendy

Chen Junjie | Zendy; Lanza Gregory M. | Zendy; Wickline Samuel A. | Zendy

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Quantitative magnetic resonance fluorine imaging: today and tomorrow

Author(s) -

Chen Junjie,

Lanza Gregory M.,

Wickline Samuel A.

Publication year - 2010

Publication title -

wiley interdisciplinary reviews: nanomedicine and nanobiotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.175

H-Index - 72

eISSN - 1939-0041

pISSN - 1939-5116

DOI - 10.1002/wnan.87

Subject(s) - magnetic resonance imaging , nuclear magnetic resonance , fluorine , in vivo , moiety , chemistry , materials science , analytical chemistry (journal) , medicine , radiology , biology , stereochemistry , physics , organic chemistry , microbiology and biotechnology

Fluorine ( 19 F) is a promising moiety for quantitative magnetic resonance imaging (MRI). It possesses comparable magnetic resonance (MR) sensitivity to proton ( 1 H) but exhibits no tissue background signal, allowing specific and selective assessment of the administrated 19 F‐containing compounds in vivo . Additionally, the MR spectra of 19 F‐containing compounds exhibited a wide range of chemical shifts (>200 ppm). Therefore, both MR parameters (e.g., spin–lattice relaxation rate R 1 ) and the absolute quantity of molecule can be determined with 19 F MRI for unbiased assessment of tissue physiology and pathology. This article reviews quantitative 19 F MRI applications for mapping tumor oxygenation, assessing molecular expression in vascular diseases, and tracking labeled stem cells. WIREs Nanomed Nanobiotechnol 2010 2 431–440 This article is categorized under: Diagnostic Tools > Biosensing Therapeutic Approaches and Drug Discovery > Emerging Technologies

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