Premium
Quantitative magnetic resonance fluorine imaging: today and tomorrow
Author(s) -
Chen Junjie,
Lanza Gregory M.,
Wickline Samuel A.
Publication year - 2010
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.87
Subject(s) - magnetic resonance imaging , nuclear magnetic resonance , fluorine , in vivo , moiety , chemistry , small molecule , materials science , analytical chemistry (journal) , medicine , stereochemistry , radiology , biology , biochemistry , physics , organic chemistry , microbiology and biotechnology
Fluorine ( 19 F) is a promising moiety for quantitative magnetic resonance imaging (MRI). It possesses comparable magnetic resonance (MR) sensitivity to proton ( 1 H) but exhibits no tissue background signal, allowing specific and selective assessment of the administrated 19 F‐containing compounds in vivo . Additionally, the MR spectra of 19 F‐containing compounds exhibited a wide range of chemical shifts (>200 ppm). Therefore, both MR parameters (e.g., spin–lattice relaxation rate R 1 ) and the absolute quantity of molecule can be determined with 19 F MRI for unbiased assessment of tissue physiology and pathology. This article reviews quantitative 19 F MRI applications for mapping tumor oxygenation, assessing molecular expression in vascular diseases, and tracking labeled stem cells. WIREs Nanomed Nanobiotechnol 2010 2 431–440 This article is categorized under: Diagnostic Tools > Biosensing Therapeutic Approaches and Drug Discovery > Emerging Technologies