Premium
In vivo near‐infrared fluorescence imaging of cancer with nanoparticle‐based probes
Author(s) -
He Xiaoxiao,
Wang Kemin,
Cheng Zhen
Publication year - 2010
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.85
Subject(s) - autofluorescence , nanoparticle , nanotechnology , fluorescence , in vivo , molecular imaging , photon upconversion , preclinical imaging , fluorescence lifetime imaging microscopy , materials science , quantum dot , quantum yield , biophysics , luminescence , optoelectronics , optics , physics , microbiology and biotechnology , biology
The use of in vivo near‐infrared fluorescence (NIRF) imaging techniques for sensitive cancer early detection is highly desirable, because biological tissues show very low absorption and autofluorescence in the NIR spectrum window. Cancer NIRF molecular imaging relies greatly on stable, highly specific and sensitive molecular probes. Nanoparticle‐based NIRF probes have overcome some of the limitations of the conventional NIRF organic dyes, such as poor hydrophilicity and photostability, low quantum yield, insufficient stability in biological system, low detection sensitivity, etc. Therefore, a lot of efforts have been made to actively develop novel NIRF nanoparticles for in vivo cancer molecular imaging. The main focus of this article is to provide a brief overview of the synthesis, surface modification, and in vivo cancer imaging applications of nanoparticle‐based NIRF probes, including dye‐containing nanoparticles, NIRF quantum dots, and upconversion nanoparticles. WIREs Nanomed Nanobiotechnol 2010 2 349–366 This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > In Vivo Nanodiagnostics and Imaging