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High‐resolution light microscopy using luminescent nanoparticles
Author(s) -
Ohulchanskyy Tymish Y.,
Roy Indrajit,
Yong KenTye,
Pudavar Haridas E.,
Prasad Paras N.
Publication year - 2010
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.67
Subject(s) - nanomaterials , nanotechnology , nanoparticle , luminescence , materials science , quantum dot , lanthanide , nanoscopic scale , fluorescence , biosensor , microscopy , nanocrystal , chemistry , optoelectronics , optics , ion , physics , organic chemistry
This review presents recent progress in the development of the luminescent nanoparticles for confocal and multiphoton microscopy. Four classes of nanomaterials are discussed: (1) silica‐based nanoparticles doped with fluorescent molecules, (2) gold nanoparticles, (3) semiconductor nanocrystals (quantum dots/rods), and (4) nanophosphors. Special considerations are given to recently developed imaging nanoprobes, such as (1) organically modified silica (ORMOSIL) nanoparticles doped with two‐photon absorbing fluorophores, which exhibit aggregation‐enhanced fluorescence (AEF), and (2) nanophosphors (ceramic nanoparticles containing luminescent lanthanoid ions). Advantages and disadvantages of every class of nanomaterials and their specific applications are briefly discussed. WIREs Nanomed Nanobiotechnol 2010 2 162–175 This article is categorized under: Diagnostic Tools > Biosensing Nanotechnology Approaches to Biology > Nanoscale Systems in Biology