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Nanoparticles in sentinel lymph node mapping
Author(s) -
Ravizzini Gregory,
Turkbey Baris,
Barrett Tristan,
Kobayashi Hisataka,
Choyke Peter L.
Publication year - 2009
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.48
Subject(s) - lymphatic system , magnetic resonance imaging , sentinel lymph node , lymph , lymph node , optical imaging , medicine , biomedical engineering , computer science , radiology , pathology , cancer , physics , optics , breast cancer
The lymph nodes and lymphatic vessels are more difficult to access than most vascular structures. Interstitial injection of imaging agents is often necessary to opacify the lymphatics. Traditionally, radionuclide methods of sentinel node imaging have dominated this field, however, limitations in resolution and exposure to radiation have encouraged the development of newer imaging methods. Among these are magnetic resonance lymphography in which a Gadolinium labeled nanoparticle is injected and imaged providing superior anatomic resolution and assessment of lymphatic dynamics. Optical imaging employing various nanoparticles including quantum dots also provide the capability of mapping each lymphatic basin in another “color”. Taken together this “toolbox” of lymphatic imaging agents is poised to improve our understanding of the lymphatic system Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery